Activation and regulation of ATM kinase activity in response to DNA double-strand breaks

被引：432

作者：

Lee, J-H ^{[1
]}

Paull, T. T. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Mol Genet & Microbiol, Inst Cell & Mol Biol, Austin, TX 78712 USA

来源：

ONCOGENE | 2007年 / 26卷 / 56期

关键词：

ATM; MRN; DNA repair; checkpoints; TELANGIECTASIA MUTATED ATM; S-PHASE CHECKPOINT; FORKHEAD-ASSOCIATED DOMAIN; PROTEIN PHOSPHATASE 2A; ATAXIA-TELANGIECTASIA; DAMAGE RESPONSE; DEPENDENT PHOSPHORYLATION; IONIZING-RADIATION; MRE11; COMPLEX; HISTONE ACETYLTRANSFERASE;

D O I：

10.1038/sj.onc.1210872

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The ataxia-telangiectasia-mutated (ATM) protein kinase is rapidly and specifically activated in response to DNA double-strand breaks in eukaryotic cells. In this review, we summarize recent insights into the mechanism of ATM activation, focusing on the role of the Mre11/Rad50/Nbs1 (MRN) complexin this process. We also compare observations of the ATM activation process in different biological systems and highlight potential candidates for cellular factors that may participate in regulating ATM activity in human cells.

引用

页码：7741 / 7748

页数：8

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