Ionic liquids/H2O systems for the reaction of epoxides with NaN3:: a new protocol for the synthesis of 2-azidoalcohols

被引：45

作者：

Yadav, JS ^{[1
]}

Reddy, BVS ^{[1
]}

Jyothirmai, B ^{[1
]}

Murty, MSR ^{[1
]}

机构：

[1] Indian Inst Chem Technol, Div Organ Chem, Hyderabad 500007, Andhra Pradesh, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 38期

关键词：

ionic liquids (ILs); oxiranes; azidoalcohols;

D O I：

10.1016/j.tetlet.2005.07.074

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Oxiranes undergo ring opening rapidly with sodium azide in a [bmim]BF4/H2O or [bmim]PF6/H2O (2: 1) solvent system, under mild and neutral reaction conditions to afford the corresponding 2-azidoalcohols in high to quantitative yields. The remarkable features of this procedure are improved yields, enhanced reaction rates, high regioselectivity and ease of recyclability of ionic liquids (ILs). The recovered ionic liquid can be reused for four to five times but with gradual decrease in activity. (c) 2005 Published by Elsevier Ltd.

引用

页码：6559 / 6562

页数：4

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