Cancer biology - Summing up cancer stem cells

被引：96

作者：

Huntly, BJP ^{[1
]}

Gilliland, DG

机构：

[1] Univ Cambridge, Dept Haematol, Cambridge CB2 2XY, England

[2] Brigham & Womens Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

NATURE | 2005年 / 435卷 / 7046期

关键词：

D O I：

10.1038/4351169a

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Are current cancer drugs targeted at the wrong kinds of cells? A pioneering approach to the development of treatments uses a mathematical model to follow how different types of tumour cells respond to therapy.

引用

页码：1169 / 1170

页数：2

共 9 条

[1] Prospective identification of tumorigenic breast cancer cells [J].

Al-Hajj, M ;

Wicha, MS ;

Benito-Hernandez, A ;

Morrison, SJ ;

Clarke, MF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (07) :3983-3988

[2] Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell [J].

Bonnet, D ;

Dick, JE .

NATURE MEDICINE, 1997, 3 (07) :730-737

[3] Molecular mechanisms of resistance to STI571 in chronic myeloid leukemia [J].

Gorre, ME ;

Sawyers, CL .

CURRENT OPINION IN HEMATOLOGY, 2002, 9 (04) :303-307

[4] Molecular monitoring of chronic myeloid leukemia [J].

Hughes, T ;

Branford, S .

SEMINARS IN HEMATOLOGY, 2003, 40 (02) :62-68

[5] Leukaemia stem cells and the evolution of cancer-stem-cell research [J].

Huntly, BJP ;

Gilliland, DG .

NATURE REVIEWS CANCER, 2005, 5 (04) :311-321

[6] Dynamics of chronic myeloid leukaemia [J].

Michor, F ;

Hughes, TP ;

Iwasa, Y ;

Branford, S ;

Shah, NP ;

Sawyers, CL ;

Nowak, MA .

NATURE, 2005, 435 (7046) :1267-1270

[7] Imatinib induces hematologic and cytogenetic responses in patients with chronic myelogenous leukemia in myeloid blast crisis: results of a phase II study [J].

Sawyers, CL ;

Hochhaus, A ;

Feldman, E ;

Goldman, JM ;

Miller, CB ;

Ottmann, OG ;

Schiffer, CA ;

Talpaz, M ;

Guilhot, F ;

Deininger, MWN ;

Fischer, T ;

O'Brien, SG ;

Stone, RM ;

Gambacorti-Passerini, CB ;

Russell, NH ;

Reiffers, JJ ;

Shea, TC ;

Chapuis, B ;

Coutre, S ;

Tura, S ;

Morra, E ;

Larson, RA ;

Saven, A ;

Peschel, C ;

Gratwohl, A ;

Mandelli, F ;

Ben-Am, M ;

Gathmann, I ;

Capdeville, R ;

Paquette, RL ;

Druker, BJ .

BLOOD, 2002, 99 (10) :3530-3539

[8] Identification of human brain tumour initiating cells [J].

Singh, SK ;

Hawkins, C ;

Clarke, ID ;

Squire, JA ;

Bayani, J ;

Hide, T ;

Henkelman, RM ;

Cusimano, MD ;

Dirks, PB .

NATURE, 2004, 432 (7015) :396-401

[9] Imatinib induces durable hematologic and cytogenetic responses in patients with accelerated phase chronic myeloid leukemia: results of a phase 2 study [J].

Talpaz, M ;

Silver, RT ;

Druker, BJ ;

Goldman, JM ;

Gambacorti-Passerini, C ;

Guilhot, F ;

Schiffer, CA ;

Fischer, T ;

Deininger, MWN ;

Lennard, AL ;

Hochhaus, A ;

Ottmann, OG ;

Gratwohl, A ;

Baccarani, M ;

Stone, R ;

Tura, S ;

Mahon, FX ;

Fernandes-Reese, S ;

Gathmann, I ;

Capdeville, R ;

Kantarjian, HM ;

Sawyers, CL .

BLOOD, 2002, 99 (06) :1928-1937

← 1 →