Posterior cingulate metabolic changes occur in Parkinson's disease patients without dementia

被引：59

作者：

Camicioli, RM

Korzan, JR

Foster, SL

Fisher, NJ

Emery, DJ

Bastos, AC

Hanstock, CC

机构：

[1] Univ Alberta, Glenrose Rehabil Hosp, Dept Med, Div Neurol, Edmonton, AB T5G 0B7, Canada

[2] Univ Alberta, Dept Radiol & Diagnost Imaging, Edmonton, AB T6G 2M7, Canada

[3] Univ Alberta, Dept Biomed Engn, Edmonton, AB T6G 2M7, Canada

[4] Univ Alberta, Div Neurosci, Edmonton, AB T6G 2M7, Canada

来源：

NEUROSCIENCE LETTERS | 2004年 / 354卷 / 03期

基金：

加拿大健康研究院;

关键词：

Parkinson's disease; memory; magnetic resonance imaging; magnetic resonance spectroscopy; hippocampus; cingulate gyrus;

D O I：

10.1016/j.neulet.2003.09.076

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The basis for cognitive deficits in Parkinson's disease (PD) is unknown. Hippocampal atrophy has been shown in Alzheimer's disease (AD) and PD. N-Acetyl aspartate (NAA)/creatine (Cr) ratio in the posterior cingulate gyrus (PCG) is decreased in AD, but unknown in PD. Volumetric magnetic resonance (MR) imaging (at 1.5 T) determined corrected HC volume and MR spectroscopy (MRS) PCG metabolites in 12 non-demented mild to moderately affected PD patients (six male, six female) and ten controls (five male, five female). Age (PD = 60.6 years, control = 62.2; P = 0.62), education (PD = 14.1 years, controls = 118; P = 0.89) and global cognition (Mini-Mental State Exam score: PD = 28.7, controls = 29.6; P = 0.14) did not differ. Only recall (CVLT-II, P = 0.046) and NAA/Cr (PD = 1.53, controls = 1.78; P = 0.03) were decreased in PD. Memory correlated with NAA/Cr (r = 0.65, P = 0.02) in PD. In conclusion, cingulate metabolic changes occur in PD. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：177 / 180

页数：4

共 19 条

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