Precursor directed biosynthesis of novel 6-deoxyerythronolide B analogs containing non-natural oxygen substituents and reactive functionalities

被引：24

作者：

Hunziker, D

Wu, N

Kenoshita, K

Cane, DE

Khosla, C ^{[1
]}

机构：

[1] Stanford Univ, Dept Chem Engn, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Chem, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Biochem, Stanford, CA 94305 USA

[4] Brown Univ, Dept Chem, Providence, RI 02912 USA

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 04期

基金：

美国国家科学基金会;

关键词：

polyketides; blocked mutant; precursor directed biosynthesis; Evans aldol reaction;

D O I：

10.1016/S0040-4039(98)02507-6

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Feeding of synthetic precursors to a blocked mutant of 6-deoxyerythronolide B synthase (DEBS) [1] led to production of novel 6-deoxyerythronolide B analogs in vivo containing additional non-natural oxygen substituents as well as additional reactive groups. (C) 1999 Elsevier Science Ltd. All rights reserved.

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页码：635 / 638

页数：4

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