Membrane fusion: Structure snared at last

被引:24
作者
Hughson, FM [1 ]
机构
[1] Princeton Univ, Dept Mol Biol, Princeton, NJ 08544 USA
关键词
D O I
10.1016/S0960-9822(99)80008-6
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The structure of the core of the neuronal 'SNARE complex', involved in neurotransmitter release, has been determined recently. Its topological similarity to viral fusion proteins suggests how the SNARE complex might facilitate membrane fusion.
引用
收藏
页码:R49 / R52
页数:4
相关论文
共 18 条
[1]   Three-dimensional solution structure of the 44 kDa ectodomain of SIV gp41 [J].
Caffrey, M ;
Cai, ML ;
Kaufman, J ;
Stahl, SJ ;
Wingfield, PT ;
Covell, DG ;
Gronenborn, AM ;
Clore, GM .
EMBO JOURNAL, 1998, 17 (16) :4572-4584
[2]   Identification of a minimal core of the synaptic SNARE complex sufficient for reversible assembly and disassembly [J].
Fasshauer, D ;
Eliason, WK ;
Brünger, AT ;
Jahn, R .
BIOCHEMISTRY, 1998, 37 (29) :10354-10362
[3]   Structural changes are associated with soluble N-ethylmaleimide-sensitive fusion protein attachment protein receptor complex formation [J].
Fasshauer, D ;
Otto, H ;
Eliason, WK ;
Jahn, R ;
Brunger, AT .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :28036-28041
[4]   Three-dimensional structure of an evolutionarily conserved N-terminal domain of syntaxin 1A [J].
Fernandez, I ;
Ubach, J ;
Dulubova, I ;
Zhang, XY ;
Südhof, TC ;
Rizo, J .
CELL, 1998, 94 (06) :841-849
[5]  
FIEBIG KM, 1998, IN PRESS NAT STRUCT
[6]   Structure and conformational changes in NSF and its membrane receptor complexes visualized by quick-freeze/deep-etch electron microscopy [J].
Hanson, PI ;
Roth, R ;
Morisaki, H ;
Jahn, R ;
Heuser, JE .
CELL, 1997, 90 (03) :523-535
[7]  
HANSON PI, 1997, CURR OPIN NEUROBIOL, V7, P340
[8]   Enveloped viruses: A common mode of membrane fusion? [J].
Hughson, FM .
CURRENT BIOLOGY, 1997, 7 (09) :R565-R569
[9]   Genetic and morphological analyses reveal a critical interaction between the C-termini of two SNARE proteins and a parallel four helical arrangement for the exocytic SNARE complex [J].
Katz, L ;
Hanson, PI ;
Heuser, JE ;
Brennwald, P .
EMBO JOURNAL, 1998, 17 (21) :6200-6209
[10]   Regulation of SNARE complex assembly by an N-terminal domain of the t-SNARE Sso1p [J].
Nicholson, KL ;
Munson, M ;
Miller, RB ;
Filip, TJ ;
Fairman, R ;
Hughson, FM .
NATURE STRUCTURAL BIOLOGY, 1998, 5 (09) :793-802