The G to C polymorphism at-174 of the interleukin-6 gene is rare in a Southern Chinese population

被引：75

作者：

Zhai, RH

Liu, G

Yang, CM

Huang, CH

Wu, CR

Christiani, DC

机构：

[1] Harvard Univ, Sch Publ Hlth, Occupat Hlth Program, Dept Environm Hlth, Boston, MA 02115 USA

[2] Guangxi Inst Occupat Hlth, Div Pneumoconiosis, Nanning, Peoples R China

[3] Guangxi Antiepidem & Hlth Ctr, Div Occupat Hlth, Nanning, Peoples R China

[4] Gen Hosp Heshan Coal Mine Co, Heshan, Guangxi, Peoples R China

来源：

PHARMACOGENETICS | 2001年 / 11卷 / 08期

关键词：

coal miner; genetic polymorphism; interleukin-6;

D O I：

10.1097/00008571-200111000-00008

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Interleukin-6 is thought to be involved in the pathogenesis of coal workers' pneumoconiosis. Recently, a functional G to C polymorphism at position -174 of the promoter of the IL-6 gene has been described. We examined the -174 polymorphisms in 259 retired Chinese men from Guangxi province (all retired coal miners). Only one GC heterozygous and no CC homozygous variants were found. Our results suggest that the frequency of the C allele in this Chinese population is lower than in Caucasian and east Indian populations. Pharmacogenetics 11:699-701 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：699 / 701

页数：3

共 17 条

[1] Association between an interleukin-6 promoter and 3′ flanking region haplotype and reduced Alzheimer's disease risk in a German population [J].