Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours

The presence of a high number of infiltrating CD1a(+) cells in malignant neoplasms has been reported to be associated with an improved prognosis, reduced tumour recurrence and fewer metastases. This study identified a population of CD1a(+) cells within the lymphoid cell infiltrate in human ductal breast carcinoma (n = 52), which was significantly different from normal breast tissue, in which only two out of nine cases expressed CD1a(+) cells (P = 0.0192). in the majority of cases. the infiltrate was tow compared with the number of macrophages and T cells present (results not shown). There was no correlation between the number of CD1a(+) cells and tumour grade, with all tumour grades expressing similar numbers of infiltrating CD1a(+) cells. There was clear evidence, however, that the CD1a(+) cells were closely associated with tumour cells. It is likely that CD1a(+) cells have a role in antigen capture and presentation in human tumours, and this study documents the density of CD1a(+) cells in a large sample of all histological grades of human breast carcinomas.