Dose-dependent antibody response to influenza H1N1 vaccine component in elderly nursing home patients

被引：21

作者：

Remarque, EJ

de Jong, JMA

van der Klis, RJ

Masurel, N

Lighthart, GJ

机构：

[1] Leiden Univ, Med Ctr, Sect Gerontol, Dept Gen Internal Med, NL-2300 RC Leiden, Netherlands

[2] Dutch Council Resp Viruses Particular Influenza, Rotterdam, Netherlands

来源：

EXPERIMENTAL GERONTOLOGY | 1999年 / 34卷 / 01期

关键词：

influenza; immunogenicity; dose response; elderly;

D O I：

10.1016/S0531-5565(98)00060-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 [法学]; 0303 [社会学]; 100203 [老年医学];

摘要：

The effects of an increased antigen dose on HI, IgG, IgA, and IgM antibody responses to influenza A/Taiwan/1/86 (H1N1) were investigated in 92 elderly nursing-home residents (mean age 81 years) and 104 young subjects (mean age 20 years). At a standard 10-mu g dose, HI and IgG titer rises were lower in the elderly. HI titers did not improve at higher vaccine dosages. By contrast, influenza-specific IgG and IgA antibody responses were dose dependent in elderly subjects, but not in young. In the young subjects, IgM antibody responses were dose dependent. The improved antibody responses in the elderly as observed in IgG and IgA were not reflected in the HI response. Therefore, the evaluation of antibody production by HI only may lead to an underestimate of the immune response in elderly people. (C) 1999 Elsevier Science Inc. All rights reserved.

引用

页码：109 / 115

页数：7

共 21 条

[1]

ANTIBODY INDUCTION BY INFLUENZA VACCINES IN THE ELDERLY - A REVIEW OF THE LITERATURE [J].