Status of cellular immunity lacks prognostic significance in vulvar squamous carcinoma

被引：22

作者：

de Jong, R. A. ^{[1
]}

Toppen, N. L. ^{[1
]}

ten Hoor, K. A. ^{[1
]}

Boezen, H. M. ^{[2
]}

Kema, I. P. ^{[3
]}

Hollema, H. ^{[4
]}

Nijman, H. W. ^{[1
]}

机构：

[1] Univ Groningen, Dept Gynecol Oncol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[2] Univ Groningen, Dept Epidemiol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[3] Univ Groningen, Dept Lab Med, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

[4] Univ Groningen, Dept Pathol, Univ Med Ctr Groningen, NL-9700 RB Groningen, Netherlands

来源：

GYNECOLOGIC ONCOLOGY | 2012年 / 125卷 / 01期

关键词：

Vulvar carcinoma; T-lymphocytes; HLA class I; Indoleamine 2,3-dioxygenase; REGULATORY T-CELLS; TUMOR-INFILTRATING LYMPHOCYTES; ANTIGEN CLASS-I; INDOLEAMINE 2,3-DIOXYGENASE; CANCER; EXPRESSION; STAGE; SURVIVAL; ASSOCIATION; RECRUITMENT;

D O I：

10.1016/j.ygyno.2011.12.416

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Objective. It is generally recognized that the immune system has an important role in regulating cancer development. Evidence indicating a prognostic role of the immune system in vulvar carcinoma is scarce. This study investigated the presence and prognostic significance of several aspects of the immune system in vulvar squamous carcinoma. Methods. The number of intratumoral CD8(+) and Foxp3(+) T-lymphocytes, next to HLA class I (HLA-A, HLA-B/C and beta(2)-m) and indoleamine 2,3-dioxygenase (IDO) expression was determined by immunohistochemistry in a consecutively selected cohort of 286 vulvar squamous carcinoma patients, all treated in the University Medical Center Groningen, the Netherlands. Associations between immunohistochemistry expression and the influence on survival were determined. Results. The number of tumor-infiltrating CD8(+) T-lymphocytes was significantly lower in tumors with loss of HLA-A (p=0.004), HLA-B/C (p=0.024) or beta(2)-m (p=0.025) expression compared with tumors with expression of HLA class I. No association was found between the number of intratumoral CD8(+) T-lymphocytes and Foxp3(+) T-lymphocytes, HLA class I and IDO expression and survival of vulvar squamous carcinoma patients. Conclusion. Our results indicate that the immune system does not seem to have a major influence on prognosis of patients with vulvar squamous carcinoma. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：186 / 193

页数：8

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