Bioneedles as alternative delivery system for hepatitis B vaccine

被引:35
作者
Hirschberg, Hoang J. H. B. [1 ]
de Wijdeven, Gijsbert G. P. van [2 ]
Kraan, Heleen [1 ]
Amorij, Jean-Pierre [1 ]
Kersten, Gideon F. A. [1 ]
机构
[1] Netherlands Vaccine Inst, Unit R&D, Bilthoven, Netherlands
[2] Bioneedle Technol Grp BV, Eindhoven, Netherlands
关键词
Hepatitis B surface antigen; Bioneedle; Freeze drying; Stability; Adjuvant; Formulation; SURFACE-ANTIGEN; IMMUNOGENICITY; PREVALENCE; STABILITY; PAIN; FEAR;
D O I
10.1016/j.jconrel.2010.06.028
中图分类号
O6 [化学];
学科分类号
070301 [无机化学];
摘要
An alternative vaccine delivery system for needle injections is the Bioneedle. Hepatitis B surface antigen (HBsAg) was formulated with Bioneedles. Three formulations were used: plain antigen. HBsAg adjuvated with aluminum hydroxide and HBsAg with LPS-derived IpxL1. Bioneedles with HBsAg-IpxL1 were the most stable and the most immunogenic formulations. The conventional liquid alum adjuvated vaccine lost 40% of its antigenicity after 1 week at 50 degrees C whereas the HBsAg-IpxL1 Bioneedles showed no significant decrease after 3 weeks at 50 degrees C. in vivo studies revealed that the HBsAg-IpxL1 Bioneedle formulations induced comparable IgG titers as conventional liquid formulations after 2 immunizations, but higher IgG2a titers were found already after 1 immunization. The in vivo and in vitro studies showed that the Bioneedle is an attractive alternative for needle injections of HBsAg vaccines. (C) 2010 Elsevier B.V. All rights reserved.
引用
收藏
页码:211 / 217
页数:7
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