A 356-kb sequence of the subtelomeric part of the MHC class I region

被引：18

作者：

Hampe, A ^{[1
]}

Coriton, O ^{[1
]}

Andrieux, N ^{[1
]}

Carn, G ^{[1
]}

Lepourcelet, M ^{[1
]}

Mottier, S ^{[1
]}

Dréano, S ^{[1
]}

Gatius, MT ^{[1
]}

Hitte, C ^{[1
]}

Soriano, N ^{[1
]}

Galibert, F ^{[1
]}

机构：

[1] Fac Med, CNRS, UPR Recombinaisons Genet 41, F-35043 Rennes, France

来源：

DNA SEQUENCE | 1999年 / 10卷 / 4-5期

关键词：

human; genomic sequence; MHC Class I; sequence analogy; bioinformatic; repetitive DNA;

D O I：

10.3109/10425179909033955

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The subtelomeric part of the MHC Class I region contains 11 of the 21 genes described on chromosome 6 at position 6p21.3. The general organization of those and other genes resident in the region was revealed by determining a 356,376 bp sequence. Potential exons for new genes were identified by computer analysis and a large number of ESTs were selected by testing the sequence by the BLAST algorithm against the Gen-Bank nonredundant and EST databases. Most of the ESTs are clustered in two regions. In contrast, the whole HLA-gene region is crammed with LINE and SINE repeats, fragments of genes and microsatellites, which tends to hinder the identification of new genes.

引用

页码：263 / +

页数：38

共 45 条

[1] EVIDENCE FOR A POLYMORPHISM OF HLA-G GENE [J].

ALIZADEH, M ;

LEGRAS, C ;

SEMANA, G ;

LEBOUTEILLER, P ;

GENETET, B ;

FAUCHET, R .

HUMAN IMMUNOLOGY, 1993, 38 (03) :206-212

[2] Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].

Altschul, SF ;

Madden, TL ;

Schaffer, AA ;

Zhang, JH ;

Zhang, Z ;

Miller, W ;

Lipman, DJ .

NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402

[3] LOCALIZATION OF NEW GENES AND MARKERS TO THE DISTAL PART OF THE HUMAN MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) REGION AND COMPARISON WITH THE MOUSE - NEW INSIGHTS INTO THE EVOLUTION OF MAMMALIAN GENOMES [J].

AMADOU, C ;

RIBOUCHON, MT ;

MATTEI, MG ;

JENKINS, NA ;

GILBERT, DJ ;

COPELAND, NG ;

AVOUSTIN, P ;

PONTAROTTI, P .

GENOMICS, 1995, 26 (01) :9-20

[4]

ASCANIO L, 1982, CR ACAD SCI III-VIE, V295, P433

[5] The MIC gene family [J].

Bahram, S ;

Spies, T .

RESEARCH IN IMMUNOLOGY, 1996, 147 (05) :328-333

[6] A 2ND LINEAGE OF MAMMALIAN MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I GENES [J].

BAHRAM, S ;

BRESNAHAN, M ;

GERAGHTY, DE ;

SPIES, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (14) :6259-6263

[7] THE ISOCHORE ORGANIZATION OF THE HUMAN GENOME AND ITS EVOLUTIONARY HISTORY - A REVIEW [J].

BERNARDI, G .

GENE, 1993, 135 (1-2) :57-66

[8] A new DNA sequence assembly program [J].

Bonfield, JK ;

Smith, KF ;

Staden, R .

NUCLEIC ACIDS RESEARCH, 1995, 23 (24) :4992-4999

[9] A HUMAN HOMOLOG TO THE YEAST OMNIPOTENT SUPPRESSOR-45 MAPS 100 KB CENTROMERIC TO HLA-A [J].

CHAUVEL, B ;

DORVAL, I ;

FERGELOT, P ;

PICHON, L ;

GIFFON, T ;

GICQUEL, I ;

LEGALL, JY ;

DAVID, V .

IMMUNOGENETICS, 1995, 41 (06) :380-382

[10] CLONING OF A NEW FINGER PROTEIN GENE (ZNF173) WITHIN THE CLASS-I REGION OF THE HUMAN MHC [J].

CHU, TW ;

CAPOSSELA, A ;

COLEMAN, R ;

GOEI, VL ;

NALLUR, G ;

GRUEN, JR .

GENOMICS, 1995, 29 (01) :229-239

← 1 2 3 4 5 →