Short asymmetric synthesis of (-)- and (+)-cis-lauthisan

被引：32

作者：

Carreño, MC ^{[1
]}

Des Mazery, R ^{[1
]}

Urbano, A ^{[1
]}

Colobert, F ^{[1
]}

Solladié, G ^{[1
]}

机构：

[1] Univ Strasbourg, CNRS, ECPM, Lab Stereochim Associe, F-67087 Strasbourg, France

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 10期

关键词：

D O I：

10.1021/ol050620a

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The asymmetric synthesis of both enantiomers of cis-lauthisan (3) is achieved in only six steps from diethyl pimelate (4), the key steps being the diastereodivergent reduction of beta-ketosulfoxide 7 and the highly cis-stereoselective Et3SiH/TMSOTf-promoted reductive cyclization of enantiopure hydroxy sulfinyl ketones (S)-14 and (R)-14.

引用

页码：2039 / 2042

页数：4

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