Molybdenum complexes of the anticancer drug 6-mercaptopurine

Two Mo(II) complexes [Mo-2(II)(MP)(4)(H2O)(2)]. 2H(2)O (1), Mo-2(II)(MP)(2)(H2O)(2) (2) and a Mo(IV) complex, [(Mo3S7)-S-IV(MP)(3)]Br (3), have been prepared. The complexes have been characterised by elemental analysis, thermogravimetry, FAB mass spectrometry, and their magnetic susceptibility data have been determined. [Mo-2(II)(MP)(4)(H2O)(2)]. 2H(2)O (1) is a dimer. Mo-2(II)(MP)(2)(H2O)(2) (2) adopts a polymeric structure. Compounds 1 and 3 contain monodeprotonated MP- ligands, whereas doubly deprotonated MP2- anions occur in 2. In both structures of 1 and 2, the MP ligand bridges the molybdenum atoms in the quadruply bonded Mo, dimers through atoms N(7) and S(6). [(Mo3S7)-S-IV(MP)(3)]Br (3) consists of a monomeric Mo3S7 clusterion with one MP ligand per Mo atom chelated by atoms N(7) and S(6). The formation reactions of the complexes in solution have been investigated by C-13-NMR spectroscopy. (C) 1998 Elsevier Science S.A. All rights reserved.