Iron overload following manganese exposure in cultured neuronal, but not neuroglial cells

被引：58

作者：

Zheng, W

Zhao, QQ

机构：

[1] Columbia Univ, Sch Publ Hlth, Div Environm Hlth Sci, New York, NY 10032 USA

[2] Columbia Univ, Coll Phys & Surg, Dept Pharmacol, New York, NY 10032 USA

来源：

BRAIN RESEARCH | 2001年 / 897卷 / 1-2期

关键词：

manganese; iron; transferrin receptor; transferrin receptor mRNA; uptake; PC12; cell; astrocyte;

D O I：

10.1016/S0006-8993(01)02049-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Our previous studies show that manganese (Mn) exposure inhibits aconitase, an enzyme regulating the proteins responsible for cellular iron (Fe) equilibrium. This study was performed to investigate whether Mn intoxication leads to an altered cellular Fe homeostasis in cultured neuronal or neuroglial cells as a result of disrupted Fe regulation. Our results reveal a significant increase in the expression of transferrin receptor (TfR) mRNAs and a corresponding increase in cellular Fe-59 net uptake by PC12 cells, but not astrocytes, following Mn exposure. These findings suggest that alteration by Mn of cellular Fe homeostasis may contribute to Mn-induced neuronal cytotoxicity. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：175 / 179

页数：5

共 21 条

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