A prospective case-control study of the role of astrovirus in acute diarrhea among hospitalized young children

被引:82
作者
Dennehy, PH
Nelson, SM
Spangenberger, S
Noel, JS
Monroe, SS
Glass, RI
机构
[1] Rhode Isl Hosp, Dept Pediat, Providence, RI USA
[2] Brown Med Sch, Providence, RI USA
[3] CDCP, Natl Ctr Infect Dis, Div Viral & Rickettsial Dis, Viral Gastroenteritis Unit, Atlanta, GA USA
关键词
D O I
10.1086/321007
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
This study examines the importance of astroviruses as a cause of acute diarrhea in hospitalized children <10 years old during a 5-year period. Stools were screened by electron microscopy and were tested for astrovirus, rotavirus, and enteric adenovirus by EIA. During the study, 14.6% of hospitalized children had diarrhea. Astroviruses were second only to rotaviruses as etiologic agents of both community-acquired and nosocomial diarrhea. Community-acquired astrovirus infection occurred in 6.8% of patients, and nosocomial disease occurred in 16.2%. Most cases occurred from March through June, and astrovirus type 1 was the most common. The symptoms of astrovirus-infected children were similar to those of children with rotavirus infection. However, astrovirus-infected children had a lower median age, less dehydration, and lower symptom severity scores and were less likely to have been admitted for gastroenteritis than were children with rotavirus. Astrovirus, for which only rehydration therapy is required, should be considered as another common diarrheal pathogen in children <2 years old.
引用
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页码:10 / 15
页数:6
相关论文
共 30 条
  • [1] Prevalence of group A rotavirus, human calicivirus, astrovirus, and adenovirus type 40 and 41 infections among children with acute gastroenteritis in Dijon, France
    Bon, F
    Fascia, P
    Dauvergne, M
    Tenenbaum, D
    Planson, H
    Petion, AM
    Pothier, P
    Kohli, E
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1999, 37 (09) : 3055 - 3058
  • [2] PEDIATRIC VIRAL GASTROENTERITIS DURING 8 YEARS OF STUDY
    BRANDT, CD
    KIM, HW
    RODRIGUEZ, WJ
    ARROBIO, JO
    JEFFRIES, BC
    STALLINGS, EP
    LEWIS, C
    MILES, AJ
    CHANOCK, RM
    KAPIKIAN, AZ
    PARROTT, RH
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1983, 18 (01) : 71 - 78
  • [3] ASTROVIRUS-ASSOCIATED DIARRHEA AMONG GUATEMALAN AMBULATORY RURAL CHILDREN
    CRUZ, JR
    BARTLETT, AV
    HERRMANN, JE
    CACERES, P
    BLACKLOW, NR
    CANO, F
    [J]. JOURNAL OF CLINICAL MICROBIOLOGY, 1992, 30 (05) : 1140 - 1144
  • [4] CANDIDATE ADENOVIRUS-40 AND ADENOVIRUS-41 - FASTIDIOUS ADENOVIRUSES FROM HUMAN INFANT STOOL
    DEJONG, JC
    WIGAND, R
    KIDD, AH
    WADELL, G
    KAPSENBERG, JG
    MUZERIE, CJ
    WERMENBOL, AG
    FIRTZLAFF, RG
    [J]. JOURNAL OF MEDICAL VIROLOGY, 1983, 11 (03) : 215 - 231
  • [5] ASTROVIRUSES AS A CAUSE OF NOSOCOMIAL OUTBREAKS OF INFANT DIARRHEA
    ESAHLI, H
    BREBACK, K
    BENNET, R
    EHRNST, A
    ERIKSSON, M
    HEDLUND, KO
    [J]. PEDIATRIC INFECTIOUS DISEASE JOURNAL, 1991, 10 (07) : 511 - 515
  • [6] FLORES J, 1987, LANCET, V1, P882
  • [7] THE INCIDENCE OF VIRAL-ASSOCIATED DIARRHEA AFTER ADMISSION TO A PEDIATRIC HOSPITAL
    FORDJONES, EL
    MINDORFF, CM
    GOLD, R
    PETRIC, M
    [J]. AMERICAN JOURNAL OF EPIDEMIOLOGY, 1990, 131 (04) : 711 - 718
  • [8] Glass RI, 1996, ARCH VIROL, P287
  • [9] ASTROVIRUSES AS A CAUSE OF GASTROENTERITIS IN CHILDREN
    HERRMANN, JE
    TAYLOR, DN
    ECHEVERRIA, P
    BLACKLOW, NR
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 1991, 324 (25) : 1757 - 1760
  • [10] *INT COMM TAX VIR, 1995, ARCH VIROL, V10, P1