Polymorphisms in toll-like receptor genes and susceptibility to pulmonary aspergillosis

被引：190

作者：

Carvalho, A. ^{[1
]}

Pasqualotto, A. C. ^{[2
,3
]}

Pitzurra, L. ^{[4
]}

Romani, L. ^{[4
]}

Denning, D. W. ^{[2
,3
]}

Rodrigues, F. ^{[1
]}

机构：

[1] Univ Minho, Sch Hlth Sci, Life & Hlth Sci Res Inst ICVS, P-4710057 Braga, Portugal

[2] Univ Manchester, Sch Med, Manchester, Lancs, England

[3] Wythenshawe Hosp, Manchester M23 9LT, Lancs, England

[4] Univ Perugia, Dept Expt Med & Biochem Sci, I-06100 Perugia, Italy

来源：

JOURNAL OF INFECTIOUS DISEASES | 2008年 / 197卷 / 04期

关键词：

D O I：

10.1086/526500

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46;P = .003). Susceptibility to allergic bronchopulmonary aspergillosis was associated with allele C on T-1237C (TLR9) (OR, 2.49; P = .043). No particular polymorphism was associated with severe asthma with fungal sensitization. These findings reinforce the importance of innate immunity in the pathogenesis of different forms of aspergillosis.

引用

页码：618 / 621

页数：4

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