Detailed analysis of the CD8+ T-Cell response following adenovirus vaccination

被引：65

作者：

Yang, TC ^{[1
]}

Dayball, K ^{[1
]}

Wan, YH ^{[1
]}

Bramson, J ^{[1
]}

机构：

[1] McMaster Univ, Dept Pathol & Mol Med, Ctr Gene Therapeut, Hamilton, ON L8N 3Z5, Canada

来源：

JOURNAL OF VIROLOGY | 2003年 / 77卷 / 24期

关键词：

D O I：

10.1128/JVI.77.24.13407-13411.2003

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response.

引用

页码：13407 / 13411

页数：5

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