Muscle maturation: implications for gene therapy

被引：30

作者：

van Deutekom, JCT ^{[1
]}

Hoffman, EP

Huard, J

机构：

[1] Childrens Hosp Pittsburgh, Musculoskeletal Res Ctr, Dept Orthopaed Surg, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Mol Genet & Biochem & Human Genet, Pittsburgh, PA 15261 USA

[3] Childrens Hosp, Dept Orthopaed Surg & Mol Genet & Biochem, Pittsburgh, PA 15213 USA

[4] Univ Pittsburgh, Dept Orthopaed Surg & Mol Genet & Biochem, Pittsburgh, PA 15213 USA

来源：

MOLECULAR MEDICINE TODAY | 1998年 / 4卷 / 05期

关键词：

D O I：

10.1016/S1357-4310(98)01231-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Skeletal muscle is a promising target tissue for gene therapy for both muscle and non-muscle disorders. A variety of methods have been studied to transfer genes into skeletal muscle, including retroviral, adenoviral and herpes simplex viral vectors. However, various factors impede muscle-based viral gene therapy. Here, we discuss why some viral vectors cannot efficiently transduce mature muscle fibers, and describe some new approaches to overcome this barrier.

引用

页码：214 / 220

页数：7

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