Fetal toxoplasmosis and negative amniocentesis: necessity of an ultrasound follow-up

被引:17
作者
Gay-Andrieu, F
Marty, P
Pialat, J
Sournies, G
de Laforte, TD
Peyron, F
机构
[1] Hop Croix Rousse, Lab Parasitol & Pathol Exot, F-69317 Lyon 04, France
[2] CHU Nice, Hop Archet, Lab Parasitol Mycol, Nice, France
[3] Cabinet Anat & Cytol Pathol, Limonest, France
[4] Cabinet Gynecol Med, Lyon, France
关键词
fetal toxoplasmosis; amniocentesis; PCR; ultrasound follow-up;
D O I
10.1002/pd.632
中图分类号
Q3 [遗传学];
学科分类号
071007 ; 090102 ;
摘要
Prenatal diagnosis of congenital toxoplasmosis relies on the PCR test on amniotic fluid and ultrasound follow-up of the fetus. We report two cases of toxoplasma infection during the first trimester of gestation with a discrepant diagnosis of fetal infection. PCR performed more than four weeks after the estimated date of contamination was negative. Ultrasound follow-up was normal up to the third trimester when major hydrocephalus was detected, leading to pregnancy termination. In both cases, post-mortem examination revealed a diffuse infection with severe brain lesions. These observations confirm the necessity to continue a monthly ultrasound follow-up, even if amniocentesis is negative, in case of fetal toxoplasma infection in pregnancy. Copyright (C) 2003 John Wiley Sons, Ltd.
引用
收藏
页码:558 / 560
页数:3
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