Fluorine-18 deoxyglucose positron emission tomography for the detection of bone metastases in patients with non-small cell lung cancer

被引:213
作者
Bury, T
Barreto, A
Daenen, F
Barthelemy, N
Ghaye, B
Rigo, P
机构
[1] CHU Sart Tilman, Dept Pneumol, B-4000 Liege, Belgium
[2] CHU Sart Tilman, Dept Nucl Med, B-4000 Liege, Belgium
[3] CHU Sart Tilman, Dept Radiat Therapy, B-4000 Liege, Belgium
[4] CHU Sart Tilman, Dept Radiol, B-4000 Liege, Belgium
关键词
positron emission tomography; lung neoplasm; bone metastasis;
D O I
10.1007/s002590050291
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
Despite advances in morphological imaging, some patients with lung cancer are found to have non resectable disease at surgery or die of recurrence within a year of surgery. At present, metastatic bone involvement is usually assessed using bone scintigraphy, which has a high sensitivity but a poor specificity. We have attempted to evaluate the utility of the fluorine-18 deoxyglucose positron emission tomography (FDG PET) for the detection of bone metastasis. One hundred and ten consecutive patients with histological diagnosis of non-small cell lung cancer (NSCLC) who underwent both FDG PET and bone scintigraphy were selected for this review. In this group, there were 43 patients with metastatic disease (stage IV). Among these, 21 (19% of total group) had one or several bone metastases confirmed by biopsy (n = 8) or radiographic techniques (n = 13). Radionuclide bone scanning correctly identified 54 out of 89 cases without osseous involvement and 19 out of 21 osseous involvements. On the other hand, FDG PET correctly identified the absence of osseous involvement in 87 out of 89 patients and the presence of bone metastasis in 19 out of 21 patients. Thus using PET there were two false-negative and two false-positive cases. PET and bone scanning had, respectively, an accuracy of 96% and 66% in the evaluation of osseous involvement in patients with NSCLC. In conclusion, our data suggest that whole-body FDG PET may be useful in detecting bone metastases in patients with known NSCLC.
引用
收藏
页码:1244 / 1247
页数:4
相关论文
共 29 条
  • [1] Staging of the mediastinum: Value of positron emission tomography imaging in non-small cell lung cancer
    Bury, T
    Paulus, P
    Dowlati, A
    Corhay, JL
    Weber, T
    Ghaye, B
    Schoffers, J
    Limet, R
    Albert, A
    Rigo, P
    Radermecker, M
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (12) : 2560 - 2564
  • [2] Evaluation of the solitary pulmonary nodule by positron emission tomography imaging
    Bury, T
    Dowlati, A
    Paulus, P
    Corhay, JL
    Benoit, T
    Kayembe, JM
    Limet, R
    Rigo, P
    Radermecker, M
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1996, 9 (03) : 410 - 414
  • [3] Whole-body 18FDG positron emission tomography in the staging of non-small cell lung cancer
    Bury, T
    Dowlati, A
    Paulus, P
    Corhay, JL
    Hustinx, R
    Ghaye, B
    Radermecker, M
    Rigo, P
    [J]. EUROPEAN RESPIRATORY JOURNAL, 1997, 10 (11) : 2529 - 2534
  • [4] MEDIASTINAL STAGING OF NON-SMALL-CELL LUNG-CANCER WITH POSITRON EMISSION TOMOGRAPHY
    CHIN, R
    WARD, R
    KEYES, JW
    CHOPLIN, RH
    REED, JC
    WALLENHAUPT, S
    HUDSPETH, AS
    HAPONIK, EF
    [J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 1995, 152 (06) : 2090 - 2096
  • [5] COWAN RJ, 1973, CANCER, V32, P887, DOI 10.1002/1097-0142(197310)32:4<887::AID-CNCR2820320420>3.0.CO
  • [6] 2-7
  • [7] DONATO A, 1979, ANN THORAC SURG, V27, P301
  • [8] Diagnostic bone scanning in oncology
    Krasnow, AZ
    Hellman, RS
    Timins, ME
    Collier, BD
    Anderson, T
    Isitman, AT
    [J]. SEMINARS IN NUCLEAR MEDICINE, 1997, 27 (02) : 107 - 141
  • [9] WHOLE-BODY F-18 FLUORODEOXYGLUCOSE POSITRON EMISSION TOMOGRAPHY IN PREOPERATIVE EVALUATION OF LUNG-CANCER
    LEWIS, P
    GRIFFIN, S
    MARSDEN, P
    GEE, T
    NUNAN, T
    MALSEY, M
    DUSSEK, J
    [J]. LANCET, 1994, 344 (8932) : 1265 - 1266
  • [10] BONE-SCINTIGRAPHY IN LUNG-CANCER - A REAPPRAISAL
    MERRICK, MV
    MERRICK, JM
    [J]. BRITISH JOURNAL OF RADIOLOGY, 1986, 59 (708) : 1185 - 1194