Opening of the blood-brain barrier preceding cortical edema in a severe attack of FHM type II

被引：82

作者：

Dreier, JP

Jurkat-Rott, K

Petzold, GC

Tomkins, O

Klingebiel, R

Kopp, UA

Lehmann-Horn, F

Friedman, A

Dichgans, M

机构：

[1] Charite Univ Med, Dept Neurol, D-10117 Berlin, Germany

[2] Charite Univ Med, Dept Expt Neurol, D-10117 Berlin, Germany

[3] Charite Univ Med, Dept Neuroradiol, D-10117 Berlin, Germany

[4] Charite Univ Med, Dept Physiol, D-10117 Berlin, Germany

[5] Univ Ulm, Dept Appl Physiol, D-89069 Ulm, Germany

[6] Ben Gurion Univ Negev, Zlotowski Ctr Neurosci, Dept Neurosurg, IL-84105 Beer Sheva, Israel

[7] Univ Munich, Klinikum Grosshadern, Dept Neurol, Munich, Germany

来源：

NEUROLOGY | 2005年 / 64卷 / 12期

关键词：

D O I：

10.1212/01.WNL.0000176298.63840.99

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The authors report a patient with familial hemiplegic migraine type II who developed a long-lasting attack including fever, right-sided hemiplegia, aphasia, and coma. Quantitative analysis of early gadolinium-enhanced MRI revealed a mild but significant left-hemispheric blood-brain barrier (BBB) opening limited to the cortex and preceding cortical edema. The findings suggest that the delayed cortical edema was vasogenic in the severe migraine aura variant of this ATP1A2 mutation carrier.

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页码：2145 / 2147

页数：3

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