Magnetic mitoxantrone nanoparticle detection by histology, X-ray and MRI after magnetic tumor targeting

被引：116

作者：

Alexiou, C

Arnold, W

Hulin, P

Klein, RJ

Renz, H

Parak, FG

Bergemann, C

Lübbe, AS

机构：

[1] Tech Univ Munich, Klinikum Rechts Isar, Dept Otorhinolaryngol Head & Neck Surg, D-81675 Munich, Germany

[2] Dept Expt Oncol & Therapeut Res, Munich, Germany

[3] Tech Univ Munich, Pharm Klinikum Rechts Isar, D-81675 Munich, Germany

[4] Tech Univ Munich, Dept Phys E17, Munich, Germany

[5] Chemicell, Berlin, Germany

[6] Cecilien Klin, Bad Lippspringe, Germany

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2001年 / 225卷 / 1-2期

关键词：

magnetic drug targeting; mitoxantrone; magnetic particles; rabbit; cancer treatment; coated ferrofluids; starch; intraarterial administration; in vivo targeting; ferrofluid; histology; X-ray imaging; MR imaging; digital subtraction angiography; DSA; VX-2 squamous cell carcinoma; tumor model; chemotherapy;

D O I：

10.1016/S0304-8853(00)01256-7

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Ferrofluids coated with starch polymers can be used as biocompatible carriers. Bound to medical drugs, such magnetic particles can be enriched in a desired body compartment using an external magnetic field. In the present study, we confirm the enrichment of ferrofluids in tumor tissue using histological investigations and conventional imaging techniques, i.e. X-ray and MRI. (C) 2001 Elsevier Science B.V. All rights reserved.

引用

页码：187 / 193

页数：7

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