Suzuki-Miyaura coupling reaction by PdII-catalyzed aromatic C-H bond activation directed by an N-alkyl acetamino group

被引：285

作者：

Shi, Zhangjie ^{[1
]}

Li, Bijie

Wan, Xiaobing

Cheng, Jiang

Fang, Zhao

Cao, Bin

Qin, Changming

Wang, Yang

机构：

[1] Chinese Acad Sci, State Keu Lab Organomet Chem, Shanghai 200032, Peoples R China

[2] Peking Univ, PKU Green Chem Ctr, Coll Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China

[3] Peking Univ, Coll Med, Minist Educ, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China

[4] Wenzhou Univ, Coll Chem & Mat Sci, Wenzhou 3250027, Peoples R China

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2007年 / 46卷 / 29期

关键词：

C-C coupling; C-H activation; electrophilic substitution; palladium; Suzuki-Miyaura reaction;

D O I：

10.1002/anie.200700590

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) A seamless join: An efficient method to construct a C(sp2)-C(sp2) bond has been developed by using a Suzuki-Miyaura-type coupling of N-alkyl acetanilides with boronic acids. The reaction was catalyzed by a PdII species and the C-H bond activation was directed by the acetamino group (see scheme). This reaction offers a halogen-free method to construct complicated structures. © 2007 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5554 / 5558

页数：5

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