Antioxidant properties of butein isolated from Dalbergia odorifera

被引:100
作者
Cheng, ZJ
Kuo, SC
Chan, SC
Ko, FN
Teng, CM
机构
[1] Natl Taiwan Univ, Coll Med, Inst Pharmacol, Taipei, Taiwan
[2] China Med Coll, Grad Inst Pharmaceut Chem, Taichung, Taiwan
来源
BIOCHIMICA ET BIOPHYSICA ACTA-LIPIDS AND LIPID METABOLISM | 1998年 / 1392卷 / 2-3期
关键词
antioxidant; lipid peroxidation; low density lipoprotein; butein; xanthine oxidase; (Dalbergia odorifera);
D O I
10.1016/S0005-2760(98)00043-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The antioxidant properties of butein, isolated from Dalbergia odorifera T. Chen, were investigated in this study. Butein inhibited iron-induced lipid peroxidation in rat brain homogenate in a concentration-dependent manner with an IC50, 3.3 +/- 0.4 mu M. It was as potent as alpha-tocopherol in reducing the stable free radical diphenyl-2-picrylhydrazyl (DPPH) with an IC0.200, 9 2 +/- 1.8 mu M. It also inhibited the activity of xanthine oxidase with an IC50, 5.9 +/- 0.3 mu M. Besides, butein scavenged the peroxyl radical derived from 2,2-azobis(2-amidinopropane) dihydrochloride (AAPH) in aqueous phase, but not that from 2,2-azobis(2,4-dimethylvaleronitrile) (AMVN) in hexane. Furthermore, butein inhibited copper-catalyzed oxidation of human low-density lipoprotein (LDL), as measured by conjugated dienes and thiobarbituric acid-reactive substance (TBARS) formations, and electrophoretic mobility in a concentration-dependent manner. Spectral analysis revealed that butein was a chelator of ferrous and copper ions. It is proposed that butein serves as a powerful antioxidant against lipid and LDL peroxidation by its versatile free radical scavenging actions and metal ion chelation. (C) 1998 Elsevier Science B.V.
引用
收藏
页码:291 / 299
页数:9
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