Nucleoside homodimerisation by cross metathesis

被引：20

作者：

Batoux, N

Benhaddou-Zerrouki, R

Bressolier, P

Granet, R

Laumont, G

Aubertin, AM

Krausz, P

机构：

[1] Univ Limoges, Lab Chim Subst Nat, F-87060 Limoges, France

[2] Fac Med Strasbourg, Inst Virol, INSERM, Unite 74, F-67000 Strasbourg, France

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 08期

关键词：

D O I：

10.1016/S0040-4039(00)02292-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cross metathesis of 3'-allylic analogues of thymidine, 2'-deoxyuridine and 2'-deoxycytidine is used to obtain nucleoside dimers, in which an unsaturated hydrocarbon chain links the 3' positions of the sugar moieties. The biological activity on HIV infected cells was also evaluated. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：1491 / 1493

页数：3

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