The contribution of pneumolysin to the pathogenicity of Streptococcus pneumoniae

被引：100

作者：

Paton, JC ^{[1
]}

机构：

[1] WOMENS & CHILDRENS HOSP,MOLEC MICROBIOL UNIT,ADELAIDE,SA 5006,AUSTRALIA

来源：

TRENDS IN MICROBIOLOGY | 1996年 / 4卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/0966-842X(96)81526-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The antiphagocytic polysaccharide capsule of Streptococcus pneumoniae has long been been considered the principal virulence determinant of this organism. However, there is growing evidence that the toxin pneumolysin plays an important role in the pathogenesis of pneumococcal disease and may thus be a significant additional target for vaccine development.

引用

页码：103 / 106

页数：4

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