Explaining the bias in the 23S rRNA gene mutations associated with clarithromycin resistance in clinical isolates of Helicobacter pylori

被引：48

作者：

Debets-Ossenkopp, YJ

Brinkman, AB

Kuipers, EJ

Vandenbroucke-Grauls, CMJE

Kusters, JG

机构：

[1] Free Univ Amsterdam Hosp, Dept Clin Microbiol & Infect Control, NL-1007 MB Amsterdam, Netherlands

[2] Free Univ Amsterdam Hosp, Dept Gastroenterol, NL-1007 MB Amsterdam, Netherlands

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1998年 / 42卷 / 10期

关键词：

D O I：

10.1128/AAC.42.10.2749

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A single point mutation in the 23S rRNA gene of Helicobacter pylori is known to confer resistance to clarithromycin. Most prevalent among clarithromycin-resistant clinical H. pylori isolates are the mutations from A-2142 to G and A-2143 to G in the 23S rRNA gene. The bias in the 23S rRNA gene mutations conferring clarithromycin resistance mag result from the higher MIC, stability of resistance, and growth rate found for the strains with the above-mentioned mutations.

引用

页码：2749 / 2751

页数：3

共 14 条

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