Is there more to folates than neural-tube defects?

被引:21
作者
Finglas, PM [1 ]
Wright, AJA [1 ]
Wolfe, CA [1 ]
Hart, DJ [1 ]
Wright, DM [1 ]
Dainty, JR [1 ]
机构
[1] Inst Food Res, Dept Nutr, Norwich NR4 7UA, Norfolk, England
关键词
folic acid; bioavailability; C-1; metabolism; gene polymorphisms; health and disease;
D O I
10.1079/PNS2003271
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
The purpose of the present paper is to review our current understanding of the chemistry and biochemistry of folic acid and related folates, and to discuss their impact on public health beyond that already established in relation to neural-tube defects. Our understanding of the fascinating world of folates and C-1 metabolism, and their role in health and disease, has come a long way since the discovery of the B-vitamin folic acid by Wills (1931), and its first isolation by Mitchell et al. (1941). However, there is still much to do in perfecting methods for the measurement of folate bioavailability, and status, with a high extent of precision and accuracy. Currently, examination of the relationships between common gene polymorphisms involved in C-1 metabolism and folate bioavailability and folate status, morbidity, mortality and longevity is evaluated as a series of individual associations. However, in the future, examination of the concurrent effects of such common gene polymorphisms may be more beneficial.
引用
收藏
页码:591 / 598
页数:8
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