β-carotene with vitamins E and C offers synergistic cell protection against NOx

被引：114

作者：

Böhm, F

Edge, R

McGarvey, DJ

Truscott, TG ^{[1
]}

机构：

[1] Humboldt Univ, Dept Dermatol Charite, D-10117 Berlin, Germany

[2] Univ Keele, Dept Chem, Keele ST5 5BG, Staffs, England

来源：

FEBS LETTERS | 1998年 / 436卷 / 03期

关键词：

beta-carotene; lymphocyte; peroxynitrite; nitrogen dioxide; vitamin E; vitamin C;

D O I：

10.1016/S0014-5793(98)01173-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The peroxynitrite anion and the nitrogen dioxide (radical) are important toxic species which can arise in vivo from nitric oxide, Both in vivo and in vitro cell protection is demonstrated for beta-carotene in the presence of vitamin E and vitamin C. A synergistic protection is observed compared to the individual anti-oxidants and this is explained in terms of an electron transfer reaction in which the p-carotene radical is repaired by vitamin C. (C) 1998 Federation of European Biochemical Societies.

引用

页码：387 / 389

页数：3

共 22 条

[1]

BANER M, 1992, BIOCHIM BIOPHYS ACTA, V1104, P84

[2] PATHOLOGICAL IMPLICATIONS OF NITRIC-OXIDE, SUPEROXIDE AND PEROXYNITRITE FORMATION [J].