Bone remodelling: A signalling system for osteoclast regulation

被引：51

作者：

Filvaroff, E ^{[1
]}

Derynck, R

机构：

[1] Genentech Inc, Dept Endocrinol, S San Francisco, CA 94080 USA

[2] Univ Calif San Francisco, Dept Growth & Dev, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Anat, Cell Biol Program, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Dept Anat, Program Dev Biol, San Francisco, CA 94143 USA

来源：

CURRENT BIOLOGY | 1998年 / 8卷 / 19期

关键词：

D O I：

10.1016/S0960-9822(98)70434-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Two physiological regulators of osteoclast maturation have recently been identified: the secreted protein osteoprotegerin and the cell-surface ligand to which it binds. These proteins are likely to play an important part in the control of bone resorption, but are also likely to have important roles in other tissues.

引用

页码：R679 / R682

页数：4

共 25 条

[1] A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function [J].

Anderson, DM ;

Maraskovsky, E ;

Billingsley, WL ;

Dougall, WC ;

Tometsko, ME ;

Roux, ER ;

Teepe, MC ;

DuBose, RF ;

Cosman, D ;

Galibert, L .

NATURE, 1997, 390 (6656) :175-179

[2] EFFECT OF DEGENERATIVE SPINAL AND AORTIC CALCIFICATION ON BONE-DENSITY MEASUREMENTS IN POSTMENOPAUSAL WOMEN - LINKS BETWEEN OSTEOPOROSIS AND CARDIOVASCULAR-DISEASE [J].

BANKS, LM ;

LEES, B ;

MACSWEENEY, JE ;

STEVENSON, JC .

EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, 1994, 24 (12) :813-817

[3] osteoprotegerin-deficient mice develop early onset osteoporosis and arterial calcification [J].

Bucay, N ;

Sarosi, I ;

Dunstan, CR ;

Morony, S ;

Tarpley, J ;

Capparelli, C ;

Scully, S ;

Tan, HL ;

Xu, WL ;

Lacey, DL ;

Boyle, WJ ;

Simonet, WS .

GENES & DEVELOPMENT, 1998, 12 (09) :1260-1268

[4]

Cecchini MG, 1997, MOL REPROD DEV, V46, P75

[5] GENERATION OF OSTEOCLAST-INDUCTIVE AND OSTEOCLASTOGENIC CELL-LINES FROM THE H-2K(B)TSA58 TRANSGENIC MOUSE [J].

CHAMBERS, TJ ;

OWENS, JM ;

HATTERSLEY, G ;

JAT, PS ;

NOBLE, MD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (12) :5578-5582

[6] Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL [J].

Emery, JG ;

McDonnell, P ;

Burke, MB ;

Deen, KC ;

Lyn, S ;

Silverman, C ;

Dul, E ;

Appelbaum, ER ;

Eichman, C ;

DiPrinzio, R ;

Dodds, RA ;

James, IE ;

Rosenberg, M ;

Lee, JC ;

Young, PR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (23) :14363-14367

[7] Increased expression of TGF-beta 2 in osteoblasts results in an osteoporosis-like phenotype [J].

Erlebacher, A ;

Derynck, R .

JOURNAL OF CELL BIOLOGY, 1996, 132 (1-2) :195-210

[8] TOWARD A MOLECULAR UNDERSTANDING OF SKELETAL DEVELOPMENT [J].

ERLEBACHER, A ;

FILVAROFF, EH ;

GITELMAN, SE ;

DERYNCK, R .

CELL, 1995, 80 (03) :371-378

[9] Recent developments in the understanding of the pathophysiology of osteopetrosis [J].

Felix, R ;

Hofstetter, W ;

Cecchini, MG .

EUROPEAN JOURNAL OF ENDOCRINOLOGY, 1996, 134 (02) :143-156

[10] Cytokines, growth factors and osteoclasts [J].

Heymann, D ;

Guicheux, J ;

Gouin, F ;

Passuti, N ;

Daculsi, G .

CYTOKINE, 1998, 10 (03) :155-168

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