Discovery of new chromone containing sulfonamides as potent inhibitors of bovine cytosolic carbonic anhydrase

被引：33

作者：

al-Rashida, Mariya ^{[1
]}

Ashraf, Muhammad ^{[2
]}

Hussain, Bushra ^{[2
]}

Nagra, Saeed Ahmad ^{[1
]}

Abbas, Ghulam ^{[1
]}

机构：

[1] Univ Punjab, Inst Chem, Lahore 54590, Pakistan

[2] Islamia Univ Bahawalpur, Dept Pharm, Bahawalpur 63100, Pakistan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2011年 / 19卷 / 11期

关键词：

Carbonic anhydrase; Carbonic anhydrase inhibitors; Formylchromones; Sulfonamides; ISOZYME-XII; IX;

D O I：

10.1016/j.bmc.2011.04.040

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Series of chromone containing sulfonamides were prepared by the reaction of (un)substituted 3-formylchromones with 3-aminobenzenesulfonamide and 4-aminobenzenesulfonamide. Bovine carbonic anhydrase (bCA) inhibitory activity of these newly synthesized compounds was determined. All compounds were active and possessed excellent bCA inhibitory activities with IC50 values ranged between 4.31 +/- 0.001 and 29.12 +/- 0.008 mu mol. Compounds derived from 6-fluoro-3-formylchromones were the most active. (C) 2011 Elsevier Ltd. All rights reserved.

引用

页码：3367 / 3371

页数：5

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[2]

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