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DCs and NK cells: critical effectors in the immune response to HIV-1

被引：150
作者：
Altfeld, Marcus [1 ]
Fadda, Lena [1 ]
Frleta, Davor [2 ]
Bhardwaj, Nina [2 ]
机构：
[1] Massachusetts Gen Hosp, Ragon Inst MGH MIT & Harvard, Charlestown, MA 02129 USA
[2] NYU, Langone Med Ctr, Inst Canc, New York, NY 10016 USA
来源：
NATURE REVIEWS IMMUNOLOGY | 2011年 / 11卷 / 03期
基金：
爱尔兰科学基金会;
关键词：
HUMAN-IMMUNODEFICIENCY-VIRUS; NATURAL-KILLER-CELLS; PLASMACYTOID-DENDRITIC-CELLS; CD4(+) T-CELLS; MHC CLASS-I; INTERFERON-ALPHA EXPRESSION; HIV-1-INFECTED PATIENTS; INHIBITORY RECEPTORS; TYPE-1; INFECTION; HLA-B;
D O I：
10.1038/nri2935
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Dendritic cells (DCs) and natural killer (NK) cells have central roles in antiviral immunity by shaping the quality of the adaptive immune response to viruses and by mediating direct antiviral activity. HIV-1 infection is characterized by a severe dysregulation of the antiviral immune response that starts during early infection. This Review describes recent insights into how HIV-1 infection affects DC and NK cell function, and the roles of these innate immune cells in HIV-1 pathogenesis. The importance of understanding DC and NK cell crosstalk during HIV infection for the development of effective antiviral strategies is also discussed.
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收藏
页码：176 / 186
页数：11
相关论文
共 127 条
  • [1] Sequential deregulation of NK cell subset distribution and function starting in acute HIV-1 infection
    Alter, G
    Teigen, N
    T Davis, B
    Addo, MM
    Suscovich, TJ
    Waring, MT
    Streeck, H
    Johnston, MN
    Staller, KD
    Zaman, MT
    Yu, XG
    Lichterfeld, M
    Basgoz, N
    Rosenberg, ES
    Altfeld, M
    [J]. BLOOD, 2005, 106 (10) : 3366 - 3369
  • [2] Differential natural killer cell-mediated inhibition of HIV-1 replication based on distinct KIR/HLA subtypes
    Alter, Galit
    Martin, Maureen P.
    Teigen, Nickolas
    Carr, William H.
    Suscovich, Todd J.
    Schneidewind, Arne
    Streeck, Hendrik
    Waring, Michael
    Meier, Angela
    Brander, Christian
    Lifson, Jeffrey D.
    Allen, Todd M.
    Carrington, Mary
    Altfeld, Marcus
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (12) : 3027 - 3036
  • [3] IL-10 induces aberrant deletion of dendritic cells by natural killer cells in the context of HIV infection
    Alter, Galit
    Kavanagh, Daniel
    Rihn, Suzannah
    Luteijn, Rutger
    Brooks, David
    Oldstone, Michael
    van Lunzen, Jan
    Altfeld, Marcus
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2010, 120 (06) : 1905 - 1913
  • [4] HLA Class I Subtype-Dependent Expansion of KIR3DS1+ and KIR3DL1+ NK Cells during Acute Human Immunodeficiency Virus Type 1 Infection
    Alter, Galit
    Rihn, Suzannah
    Walter, Katharine
    Nolting, Anne
    Martin, Maureen
    Rosenberg, Eric S.
    Miller, Jeffrey S.
    Carrington, Mary
    Altfeld, Marcus
    [J]. JOURNAL OF VIROLOGY, 2009, 83 (13) : 6798 - 6805
  • [5] 'Unleashed' natural killers hinder HIV
    Altfeld, Marcus
    Goulder, Philip
    [J]. NATURE GENETICS, 2007, 39 (06) : 708 - 710
  • [6] Human NK cell education by inhibitory receptors for MHC class I
    Anfossi, Nicolas
    Andre, Pascale
    Guia, Sophie
    Falk, Christine S.
    Roetynck, Sophie
    Stewart, C. Andrew
    Breso, Violette
    Frassati, Coralie
    Reviron, Denis
    Middleton, Derek
    Romagne, Francois
    Ugolini, Sophie
    Vivier, Eric
    [J]. IMMUNITY, 2006, 25 (02) : 331 - 342
  • [7] Endocytosis of HIV-1 activates plasmacytoid dendritic cells via toll-like receptor-viral RNA interactions
    Beignon, AS
    McKenna, K
    Skoberne, M
    Manches, O
    DaSilva, I
    Kavanagh, DG
    Larsson, M
    Gorelick, RJ
    Lifson, JD
    Bhardwaj, N
    [J]. JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (11) : 3265 - 3275
  • [8] CD4+NK cells can be productively infected with HIV, leading to downregulation of CD4 expression and changes in function
    Bernstein, Helene B.
    Wang, Guangwu
    Plasterer, Mary C.
    Zack, Jerome A.
    Ramasastry, Parthasarathy
    Mumenthaler, Shannon M.
    Kitchen, Christina M. R.
    [J]. VIROLOGY, 2009, 387 (01) : 59 - 66
  • [9] Natural killer cells in antiviral defense: Function and regulation by innate cytokines
    Biron, CA
    Nguyen, KB
    Pien, GC
    Cousens, LP
    Salazar-Mather, TP
    [J]. ANNUAL REVIEW OF IMMUNOLOGY, 1999, 17 : 189 - 220
  • [10] Human Immunodeficiency Virus-1 Inhibition of Immunoamphisomes in Dendritic Cells Impairs Early Innate and Adaptive Immune Responses
    Blanchet, Fabien P.
    Moris, Arnaud
    Nikolic, Damjan S.
    Lehmann, Martin
    Cardinaud, Sylvain
    Stalder, Romaine
    Garcia, Eduardo
    Dinkins, Christina
    Leuba, Florence
    Wu, Li
    Schwartz, Olivier
    Deretic, Vojo
    Piguet, Vincent
    [J]. IMMUNITY, 2010, 32 (05) : 654 - 669
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