The Deficiency of Indoleamine 2,3-Dioxygenase Aggravates the CCl4-Induced Liver Fibrosis in Mice

被引：20

作者：

Ogiso, Hideyuki ^{[1
]}

Ito, Hiroyasu ^{[1
]}

Ando, Tatsuya ^{[1
]}

Arioka, Yuko ^{[1
]}

Kanbe, Ayumu ^{[1
]}

Ando, Kazuki ^{[1
]}

Ishikawa, Tetsuya ^{[3
]}

Saito, Kuniaki ^{[4
,5
]}

Hara, Akira ^{[6
]}

Moriwaki, Hisataka ^{[2
]}

Shimizu, Masahito ^{[2
]}

Seishima, Mitsuru ^{[1
]}

机构：

[1] Gifu Univ, Grad Sch Med, Dept Informat Clin Med, Gifu, Japan

[2] Gifu Univ, Grad Sch Med, Dept Internal Med 1, Gifu, Japan

[3] Nagoya Univ, Dept Med Technol, Sch Hlth Sci, Nagoya, Aichi, Japan

[4] Kyoto Univ, Grad Sch Med, Human Hlth Sci, Kyoto, Japan

[5] Fac Med, Kyoto, Japan

[6] Gifu Univ, Grad Sch Med, Dept Tumor Pathol, Gifu, Japan

来源：

PLOS ONE | 2016年 / 11卷 / 09期

基金：

日本学术振兴会;

关键词：

INDUCED HEPATITIS MODEL; REGULATORY T-CELLS; CARBON-TETRACHLORIDE; DENDRITIC CELLS; RAT-LIVER; FULMINANT-HEPATITIS; KUPFFER CELLS; TNF-ALPHA; TRYPTOPHAN; INJURY;

D O I：

10.1371/journal.pone.0162183

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

In the present study, we examined the role of indoleamine 2,3-dioxygenase (IDO) in the development of CCl4-induced hepatic fibrosis. The liver fibrosis induced by repetitive administration with CCl4 was aggravated in IDO-KO mice compared to WT mice. In IDO-KO mice treated with CCl4, the number of several inflammatory cells and the expression of pro-inflammatory cytokines increased in the liver. In the results, activated hepatic stellate cells (HSCs) and fibrogenic factors on HSCs increased after repetitive CCl4 administration in IDO-KO mice compared to WT mice. Moreover, the treatment with L-tryptophan aggravated the CCl4-induced hepatic fibrosis in WT mice. Our findings demonstrated that the IDO deficiency enhanced the inflammation in the liver and aggravated liver fibrosis in repetitive CCl4-treated mice.

引用

页数：17

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