Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels

被引:54
作者
Morgan, CA
Rasmusson, AM
Winters, B
Hauger, RL
Morgan, J
Hazlett, G
Southwick, S
机构
[1] Yale Univ, Sch Med, Natl Ctr PTSD, VA Connecticut Healthcare Syst,Dept Psychiat, West Haven, CT 06516 USA
[2] Yale Univ, Sch Med, Phys Associate Program, West Haven, CT 06516 USA
[3] Univ Calif San Diego, VA San Diego Healthcare Syst, La Jolla, CA 92093 USA
[4] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[5] Special Forces Underwater Warfare Operat, Key West, FL USA
[6] JFK Special Warfare Training Ctr & Sch, Ft Bragg, NC USA
关键词
military stress; resilience; stress vulnerability; peptides; military active duty; veterans;
D O I
10.1016/S0006-3223(03)00433-5
中图分类号
Q189 [神经科学];
学科分类号
071006 [神经生物学];
摘要
Background: Exposure to uncontrollable stress reduces baseline plasma neuropeptide-Y levels in animals. We previously reported that baseline plasma neuropeptide-Y levels, as well as neuropeptide-Y responses to yohimbine, were lower in combat veterans with posttraumatic stress disorder, but we were unable to determine whether this was attributable to posttraumatic stress disorder or trauma exposure. The current report addresses this issue. Methods: A) Baseline plasma neuropeptide-Y levels were measured in 8 healthy combat veterans compared to 18 combat veterans with posttraumatic stress disorder and 8 healthy nontraumatized subjects; and B) Baseline plasma neuropeptide-Y levels, trauma exposure, and posttraumatic stress disorder symptoms were assessed in 41 active military personnel. Results: Plasma neuropeptide-Y was negatively associated with trauma exposure but not posttraumatic stress disorder symptoms in active duty personnel. Baseline neuropeptide-Y was reduced in combat veterans with and without posttraumatic stress disorder. Conclusions: Trauma exposure rather than posttraumatic stress disorder is associated with reduced baseline plasma neuropeptide-Y levels. Future studies must determine if neuropeptide-Y reactivity differentiates trauma-exposed individuals with and without posttraumatic stress disorder. Biol Psychiatry 2003;54:1087-1091 (C) 2003 Society of Biological Psychiatry
引用
收藏
页码:1087 / 1091
页数:5
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