Analysis of immunomodulating cytokine mRNAs in the mouse induced by mushroom polysaccharides

被引：93

作者：

Liu, F

Ooi, VEC ^{[1
]}

Fung, MC

机构：

[1] Chinese Univ Hong Kong, Dept Biol, Shatin, NT, Peoples R China

[2] Nankai Univ, Dept Microbiol, Tianjin 300071, Peoples R China

来源：

LIFE SCIENCES | 1999年 / 64卷 / 12期

关键词：

polysaccharide; cytokine; splenocyte; immunomodulation; mushroom;

D O I：

10.1016/S0024-3205(99)00027-2

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The immunomodulating action of two mushroom antitumor polysaccharides, polysaccharide-protein complex (PSPC) and lentinan, was elucidated through analysing the expression profile of cytokines during a time course (0 h to 48 h) after their administration. Among the 5 cytokine genes, the induction of a marked increase in the mRNA levels of IL-1 alpha, IL-1 beta, TNF-alpha, IFN-gamma and M-CSF by PSPC and lentinan was observed in the peritoneal exudate cells and splenocytes. However, the time point of their increased production was different after PSPC and lentinan administration.

引用

页码：1005 / 1011

页数：7

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