Arylation of halogenated pyrimidines via a Suzuki coupling reaction

被引：152

作者：

Schomaker, JM ^{[1
]}

Delia, TJ ^{[1
]}

机构：

[1] Cent Michigan Univ, Dept Chem, Malcolm H Filson Labs, Mt Pleasant, MI 48859 USA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2001年 / 66卷 / 21期

关键词：

D O I：

10.1021/jo010573+

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The Suzuki coupling reaction has been used extensively for the synthesis of a wide variety of unsymmetrical biaryl compounds. We have extended this reaction to demonstrate the utility of preparing monophenyl-, diphenyl-, or triphenylpyrimidine depending on the reaction conditions. Further, it has been shown that chloropyrimidine substrates are preferable over iodo-, bromo-, or fluoropyrimidines.

引用

页码：7125 / 7128

页数：4

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