Chemical design of nanoparticle probes for high-performance magnetic resonance imaging

被引：743

作者：

Jun, Young-Wook ^{[1
]}

Lee, Jae-Hyun ^{[1
]}

Cheon, Jinwoo ^{[1
]}

机构：

[1] Yonsei Univ, Dept Chem, Seoul 120749, South Korea

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 28期

关键词：

magnetic properties; magnetic resonance imaging; medicinal chemistry; nanoparticles; nanotechnology;

D O I：

10.1002/anie.200701674

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Synthetic magnetic nanoparticles (MNPs) are emerging as versatile probes in biomedical applications, especially in the area of magnetic resonance imaging (MRI). Their size, which is comparable to biological functional units, and their unique magnetic properties allow their utilization as molecular imaging probes. Herein, we present an overview of recent breakthroughs in the development of new synthetic MNP probes with which the sensitive and target-specific observation of biological events at the molecular and cellular levels is possible. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

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页码：5122 / 5135

页数：14

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