Myocardial perfusion modeling using MRI

In the present study, it is shown that it is possible to quantify myocardial perfusion using magnetic resonance imaging in combination with gadolinium diethylenetriaminopentaacetic acid (Gd-DTPA). Previously, a simple model and method for measuring myocardial perfusion using an inversion recovery turbo-FLASH (fast low-angle shot) sequence and Gd-DTPA has been presented, Here, an extension of the model is presented taking into account fast and slow water exchange between the compartments, enabling the calculation of the unidirectional influx constant (K-i) for Gd-DTPA, the distribution volume of Gd-DTPA (lambda), the vascular blood volume (V-b), and the time delay through the coronary arteries (Delta T). The model was evaluated by computer simulation and used on experimental results from seven healthy subjects. The results in the healthy volunteers for a region of interest placed in the anterior myocardial wall were (mean +/- SD) K-i = 54 +/- 10 ml/100 g/min, lambda = 30 +/- 3 ml/100 g, V-b = 9 +/- 2 ml/100 g, Delta T = 3.2 +/- 1.1 s. These results are in good agreement with similar results obtained by other methods.