Induction of T helper type 1 responses by a polysaccharide deacetylase from Cryptococcus neoformans

被引：19

作者：

Biondo, C ^{[1
]}

Beninati, C ^{[1
]}

Bombaci, M ^{[1
]}

Messina, L ^{[1
]}

Mancuso, G ^{[1
]}

Midiri, A ^{[1
]}

Galbo, R ^{[1
]}

Teti, G ^{[1
]}

机构：

[1] Univ Messina, Dipartimento Patol & Microbiol Sperimentale, Fac Med & Chirurg, I-98125 Messina, Italy

来源：

INFECTION AND IMMUNITY | 2003年 / 71卷 / 09期

关键词：

D O I：

10.1128/IAI.71.9.5412-5417.2003

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

A 25-kDa cryptococcal deacetylase (d25) was found here to induce cell proliferation, as well as secretion of interleukin 2 and gamma interferon, but not interleukin 4, in spleen cells from d25-immunized or Cryptococcus neoformans-infected mice. The gamma interferon, but not the interleukin 2, response was required for the protective activities of d25 immunization in a murine cryptococcosis model.

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收藏

页码：5412 / 5417

页数：6

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