A new convenient synthesis of some novel 2,6-disubstituted-pyridine derivatives

被引：16

作者：

Ali, Korany A. ^{[1
]}

机构：

[1] Natl Res Ctr, Appl Organ Chem Dept, Cairo, Egypt

来源：

ARKIVOC | 2010年

关键词：

Pyridine-2,6-bis-(3-oxo-3-propanenitrile); pyrazole; isoxazole; hydrazonoyl chloride; pyrazolopyridazine; IMMUNODEFICIENCY-VIRUS TYPE-1; REVERSE-TRANSCRIPTASE; 2-ARYLHYDRAZONO-3-OXONITRILES; CHEMISTRY; ROUTES;

D O I：

10.3998/ark.5550190.0011.b06

中图分类号：

O62 [有机化学];

学科分类号：

070303 [有机化学];

摘要：

The versatile, hitherto unreported pyridine-2,6-bis-(3-oxo-3-propanenitrile) 2 was prepared by the Claisen condensation of pyridine-2,6-dicarboxylic acid ester 1 with acetonitrile in the presence of sodium hydride. Several new pyrazoles, isoxazoles, and pyrazolopyridazine derivatives have been synthesized by the reaction of pyridine-2,6-bis-(3-oxo-3-propanenitrile) 2 with bidentate nucleophilic reagents and hydrazonoyl chloride derivatives.

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页码：55 / 63

页数：9

相关论文

共 29 条

[1]

Studies with 2-arylhydrazono-3-oxopropanals: A novel route to 4-aroyl-2-aryl-1,2,3-triazoles, 3-substituted 4-arylazopyrazoles, 2-substituted glyoxalonitrile and 3-oxoalkanonitriles [J].

Abdel-Khalik, MM ;

Agamy, SM ;

Elnagdi, MH .

ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2000, 55 (12) :1211-1215

[2]

Pyrolytic methods in organic synthesis: Novel routes for the synthesis of 3-oxoalkanenitriles, 2-acyl anilines, and 2-aroyl anilines [J].

Al-Awadi, Nouria A. ;

Abdelkhalik, Mervat M. ;

Abdelhamid, Ismail A. ;

Elnagdia, Mohamed H. .

SYNLETT, 2007, (19) :2979-2982

[3]

Al-Saleh B, 2004, J CHEM RES, P578

[4]

Cytotoxic, antioxidant activities and structure activity relationship of some newly synthesized terpenoidal oxaliplatin analogs [J].

Amr, Abd El-Galil E. ;

Ali, Korany A. ;

Abdalla, Mohamed M. .

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2009, 44 (02) :901-907

[5]

5-substituted 2-aminothiophenes as A1 adenosine receptor allosteric enhancers [J].

Aurelio, Luigi ;

Figler, Heidi ;

Flynn, Bernard L. ;

Linden, Joel ;

Scammells, Peter J. .

BIOORGANIC & MEDICINAL CHEMISTRY, 2008, 16 (03) :1319-1327

[6]

Oxidative cyclization of 3-oxopropanenitriles with α,β-unsaturated amides by manganese(III) acetate.: Regio- and stereoselective synthesis of 4-cyano-2,3-dihydrofuran-3-carboxamides [J].

Burgaz, E. Vildan ;

Yilmaz, Mehmet ;

Pekel, A. Tarik ;

Oektemer, Atilla .

TETRAHEDRON, 2007, 63 (30) :7229-7239

[7]

Dieckmann W., 1906, Chem. Ber, V38, P2989

[8]

A NEW SERIES OF PYRIDINONE DERIVATIVES AS POTENT NONNUCLEOSIDE HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 SPECIFIC REVERSE-TRANSCRIPTASE INHIBITORS [J].

DOLLE, V ;

FAN, E ;

NGUYEN, CH ;

AUBERTIN, AM ;

KIRN, A ;

ANDREOLA, ML ;

JAMIESON, G ;

TARRAGOLITVAK, L ;

BISAGNI, E .

JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (23) :4679-4686

[9]

A PHARMACOLOGICAL, CRYSTALLOGRAPHIC, AND QUANTUM-CHEMICAL STUDY OF NEW INOTROPIC AGENTS [J].

DORIGO, P ;

GAION, RM ;

BELLUCO, P ;

FRACCAROLLO, D ;

MARAGNO, I ;

BOMBIERI, G ;

BENETOLLO, F ;

MOSTI, L ;

ORSINI, F .

JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (17) :2475-2484

[10]

El-Dusouqui OME, 2006, J CHEM RES, P295