The Evolving Erythrocyte: Red Blood Cells as Modulators of Innate Immunity

被引:159
作者
Anderson, H. Luke [1 ]
Brodsky, Igor E. [2 ,3 ]
Mangalmurti, Nilam S. [3 ,4 ,5 ]
机构
[1] Univ Penn, Dept Biol, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Vet Med, Dept Pathobiol, Philadelphia, PA 19104 USA
[3] Univ Penn, Inst Immunol, Perelman Sch Med, Philadelphia, PA 19104 USA
[4] Univ Penn, Dept Med, Perelman Sch Med, Pulm Allergy & Crit Care Div, Philadelphia, PA 19104 USA
[5] Univ Penn, Penn Ctr Pulm Biol, Perelman Sch Med, Philadelphia, PA 19104 USA
基金
美国国家卫生研究院;
关键词
DUFFY ANTIGEN RECEPTOR; NON-NUCLEATED ERYTHROCYTES; TROUT ONCORHYNCHUS-MYKISS; CYTOKINE-LIKE FACTORS; MITOCHONDRIAL-DNA; ANTIMICROBIAL ACTIVITY; LUNG INJURY; INFLAMMATORY RESPONSES; DISEASE PROGRESSION; AFRICAN-AMERICANS;
D O I
10.4049/jimmunol.1800565
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
071005 [微生物学]; 100108 [医学免疫学];
摘要
The field of red cell biology is undergoing a quiet revolution. Long assumed to be inert oxygen carriers, RBCs are emerging as important modulators of the innate immune response. Erythrocytes bind and scavenge chemokines, nucleic acids, and pathogens in circulation. Depending on the conditions of the microenvironment, erythrocytes may either promote immune activation or maintain immune quiescence. We examine erythrocyte immune function through a comparative and evolutionary lens, as this framework may offer perspective into newly recognized roles of human RBCs. Next, we review the known immune roles of human RBCs and discuss their activity in the context of sepsis where erythrocyte function may prove important to disease pathogenesis. Given the limited success of immunomodulatory therapies in treating inflammatory diseases, we propose that the immunologic function of RBCs provides an understudied and potentially rich area of research that may yield novel insights into mechanisms of immune regulation.
引用
收藏
页码:1343 / 1351
页数:9
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