Chiral allylsilane additions to chiral α-substituted aldehydes

被引：11

作者：

Dias, LC ^{[1
]}

Giacomini, R ^{[1
]}

机构：

[1] Univ Estadual Campinas, Inst Quim, UNICAMP, BR-13083970 Campinas, SP, Brazil

来源：

JOURNAL OF THE BRAZILIAN CHEMICAL SOCIETY | 1998年 / 9卷 / 04期

关键词：

chiral allylsilane; transmetallation; 1,4-asymmetric induction; polyacetate derived natural products;

D O I：

10.1590/S0103-50531998000400008

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Chiral allylsilane 3 reacted with chiral alpha-methyl-beta-siloxy-aldehydes to afford the corresponding 1,4-syn-products with good diastereoselectivities independent of the absolute stereochemistry of these aldehydes. The best selectivities are observed when the reactions are carried out by transmetallation of the allylsilane 3 using Tin (IV) Chloride in CH2Cl2, at -78 degrees C, before addition of the aldehydes.

引用

页码：357 / 369

页数：13

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