Prolonged survival of a murine model of cerebral malaria by kynurenine pathway inhibition

被引：78

作者：

Clark, CJ

Mackay, GM

Smythe, GA

Bustamante, S

Stone, TW

Phillips, RS

机构：

[1] Univ Glasgow, Div Infect & Immun, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

[2] Univ New S Wales, Biomed Mass Spectrometry Facil, Sydney, NSW 2052, Australia

来源：

INFECTION AND IMMUNITY | 2005年 / 73卷 / 08期

关键词：

D O I：

10.1128/IAI.73.8.5249-5251.2005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

C57BL/6J mice infected with Plasmodium berghei ANKA develop neurological dysfunction and die within 7 days of infection. We show that treatment of infected mice with a kynurenine-3-hvdroxylase inhibitor prevents them from developing neurological symptoms and extends their life span threefold until severe anemia develops.

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收藏

页码：5249 / 5251

页数：3

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