Single nucleotide polymorphisms and recombination rate in humans

被引：223

作者：

Nachman, MW ^{[1
]}

机构：

[1] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA

来源：

TRENDS IN GENETICS | 2001年 / 17卷 / 09期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0168-9525(01)02409-X

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Levels of heterozygosity for single nucleotide polymorphisms vary by more than one order of magnitude in different regions of the human genome. Regional differences in the rate of recombination explain a substantial fraction of the variation in levels of nucleotide polymorphism, consistent with the widespread action of natural selection at the molecular level.

引用

页码：481 / 485

页数：5

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