Regulatory mechanisms for receptor protein tyrosine phosphatases

被引：35

作者：

Majeti, R

Weiss, A ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Med, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Immunol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94143 USA

来源：

CHEMICAL REVIEWS | 2001年 / 101卷 / 08期

关键词：

D O I：

10.1021/cr000085m

中图分类号：

O6 [化学];

学科分类号：

0703 [化学];

摘要：

The regulatory mechanisms for receptor protein tyrosine phosphatases (RPTP) were discussed. The regulation of RPTP by dimerization was studied and a model for negative regulation of RPTP was presented. The functional analysis of the role of the structural wedge in regulating RPTPs was done. Various other regulating mechanisms like phosphorylation and phosphate domain 2 were also described.

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页码：2441 / 2448

页数：8

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