Genetic alteration of anxiety and stress-like behavior in mice lacking CaMKIV

被引：26

作者：

Shum, Fanny W. F.

Ko, Shanelle W.

Lee, Yong-Seok

Kaang, Bong-Kiun

Zhuo, Min ^{[1
]}

机构：

[1] Univ Toronto, Fac Med, Dept Physiol, Toronto, ON M5S 1A8, Canada

[2] Seoul Natl Univ, Coll Nat Sci, Dept Biol Sci, Seoul 151742, South Korea

来源：

MOLECULAR PAIN | 2005年 / 1卷

关键词：

Anxiety; CaMKIV; Knockout mice; Microarray; Stress-induced analgesia;

D O I：

10.1186/1744-8069-1-22

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Calcium-calmodulin-dependent protein kinase IV (CaMKIV) phosphorylates the major transcription factor cyclic AMP-response element binding protein ( CREB), which plays a role in emotional behavior. Here, CaMKIV knockout mice (CaMKIV-/-) were tested in a battery of stress and anxiety-related behavioral tests, to determine if CaMKIV plays a role in emotional behavior. CaMKIV-/- exhibited a decrease in anxiety-like behavior in both the elevated plus maze and dark-light emergence tests when compared to wild-type mice. Both the acoustic startle response and prepulse inhibition of startle were decreased with the deletion of CaMKIV. In addition, CaMKIV-/- mice displayed a lack of stress-induced analgesia following restraint or cold swim stress. Our results demonstrate a key role for CaMKIV in anxiety and stress-related behavior.

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页数：9

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