Kinetics of the development and recovery of the lung from IgE-mediated inflammation - Dissociation of pulmonary eosinophilia, lung injury, and eosinophil-active cytokines

被引:55
作者
Shaver, JR [1 ]
Zangrilli, JG [1 ]
Cho, SK [1 ]
Cirelli, RA [1 ]
Pollice, M [1 ]
Hastie, AT [1 ]
Fish, JE [1 ]
Peters, SP [1 ]
机构
[1] THOMAS JEFFERSON UNIV,JEFFERSON MED COLL,DEPT MED,DIV PULM MED & CRIT CARE,PHILADELPHIA,PA 19107
关键词
D O I
10.1164/ajrccm.155.2.9032176
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Events occurring up to 16 d after antigen challenge were characterized using a novel protocol employing four bronchoscopies, two segmental antigen challenge (SAG) procedures (on Days 1 and 2), and six bronchoalveolar lavages (BALs) (on Days 1, 2, 9, and 16) in three groups: ragweed allergic asthmatics with dual phase airway reactions (AA-D), allergic asthmatics with a single early airway reaction (AA-S), and nonallergic nonasthmatic control subjects. In AA-D subjects, SAC produced a marked eosinophilic inflammatory response at 24 h associated with eosinophil degranulation (eosinophil cationic protein [ECP] in BAI. fluid) and lung injury, which largely resolved by Day 16. When the second antigen-challenged segment (SAG performed on Day 2) was lavaged 7 d after challenge (Day 9), a persistent pulmonary eosinophilia was noted accompanied by universal elevations in ECP and albumin. Eosinophil-active cytokines showed unique patterns: interleukin-5 (IL-5) increased in the antigen segment on Day 2 then returned to baseline after 7 d; granulocyte-macrophage colony-stimulating factor (CM-CSF) peaked at Day 2 but was persistently elevated throughout Day 16 in antigen segments, and increased in control segments at late time points; IL-3 levels were constant and similar in antigen and control segments. Changes were specific to AA-D subjects in comparison with control subjects. Elements of the IgE-mediated pulmonary inflammatory response differ markedly in their development and resolution.
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页码:442 / 448
页数:7
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