The diversity of the lipoxygenase family - Many sequence data but little information on biological significance

被引：277

作者：

Kuhn, H ^{[1
]}

Thiele, BJ ^{[1
]}

机构：

[1] Humboldt Univ, Bereich Med Charite, Inst Biochem, D-10115 Berlin, Germany

来源：

FEBS LETTERS | 1999年 / 449卷 / 01期

关键词：

atherogenesis; inflammation; lipid peroxidation; cell development; eicosanoid;

D O I：

10.1016/S0014-5793(99)00396-8

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Lipoxygenases form a family of lipid peroxidising enzymes, which oxygenate free and esterified polyenoic fatty acids to the corresponding hydroperoxy derivatives, They are widely distributed in both the plant and animal kingdoms, During the last couple of years more and more lipoxygenase isoforms have been discovered but for most of them the biological significance remains unclear. This review attempts to classify the currently known mammalian lipoxygenase isoforms and critically reviews the concepts for their biological importance, (C) 1999 Federation of European Biochemical Societies.

引用

页码：7 / 11

页数：5

共 49 条

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