Adoptive cell transfer: a clinical path to effective cancer immunotherapy

被引：1211

作者：

Rosenberg, Steven A. ^{[1
]}

Restifo, Nicholas P. ^{[1
]}

Yang, James C. ^{[1
]}

Morgan, Richard A. ^{[1
]}

Dudley, Mark E. ^{[1
]}

机构：

[1] NCI, Surg Branch, Ctr Canc Res, Natl Inst Hlth, Bethesda, MD 20892 USA

来源：

NATURE REVIEWS CANCER | 2008年 / 8卷 / 04期

关键词：

D O I：

10.1038/nrc2355

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adoptive cell therapy (ACT) using autologous tumour-infiltrating lymphocytes has emerged as the most effective treatment for patients with metastatic melanoma and can mediate objective cancer regression in approximately 50% of patients. The use of donor lymphocytes for ACT is an effective treatment for immunosuppressed patients who develop post-transplant lymphomas. The ability to genetically engineer human lymphocytes and use them to mediate cancer regression in patients, which has recently been demonstrated, has opened possibilities for the extension of ACT immunotherapy to patients with a wide variety of cancer types and is a promising new approach to cancer treatment.

引用

页码：299 / 308

页数：10

共 80 条

[1] T-cell receptor gene therapy of established tumors in a murine melanoma model [J].

Abad, John D. ;

Wrzensinski, Claudia ;

Overwijk, Willem ;

De Witte, Moniek A. ;

Jorritsma, Annelies ;

Hsu, Cary ;

Gattinoni, Luca ;

Cohen, Cyrille J. ;

Paulos, Chrystal M. ;

Palmer, Douglas C. ;

Haanen, John B. A. G. ;

Schumacher, Ton N. M. ;

Rosenberg, Steven A. ;

Restifo, Nicholas P. ;

Morgan, Richard A. .

JOURNAL OF IMMUNOTHERAPY, 2008, 31 (01) :1-6

[2] LYSIS OF AUTOLOGOUS MELANOMA-CELLS BY TUMOR-INFILTRATING LYMPHOCYTES - ASSOCIATION WITH CLINICAL-RESPONSE [J].

AEBERSOLD, P ;

HYATT, C ;

JOHNSON, S ;

HINES, K ;

KORCAK, L ;

SANDERS, M ;

LOTZE, M ;

TOPALIAN, S ;

YANG, J ;

ROSENBERG, SA .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1991, 83 (13) :932-937

[3] CD8+T cell immunity against a tumor/self-antigen is augmented by CD4+ T helper cells and hindered by naturally occurring T regulatory cells [J].

Antony, PA ;

Piccirillo, CA ;

Akpinarli, A ;

Finkelstein, SE ;

Speiss, PJ ;

Surman, DR ;

Palmer, DC ;

Chan, CC ;

Klebanoff, CA ;

Overwijk, WW ;

Rosenberg, SA ;

Restifo, NP .

JOURNAL OF IMMUNOLOGY, 2005, 174 (05) :2591-2601

[4] Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4 [J].

Attia, P ;

Phan, GQ ;

Maker, AV ;

Robinson, MR ;

Quezado, MM ;

Yang, JC ;

Sherry, RM ;

Topalian, SL ;

Kammula, US ;

Royal, RE ;

Restifo, NP ;

Haworth, LR ;

Levy, C ;

Mavroukakis, SA ;

Nichol, G ;

Yellin, MJ ;

Rosenberg, SA .

JOURNAL OF CLINICAL ONCOLOGY, 2005, 23 (25) :6043-6053

[5]

BERENDT MJ, 1980, J EXP MED, V151, P69, DOI 10.1084/jem.151.1.69

[6] Cytotoxic T lymphocyte therapy for Epstein-Barr virus Hodgkin's disease [J].

Bollard, CM ;

Aguilar, L ;

Straathof, KC ;

Gahn, B ;

Huls, MH ;

Rousseau, A ;

Sixbey, J ;

Gresik, MV ;

Carrum, G ;

Hudson, M ;

Dilloo, D ;

Gee, A ;

Brenner, MK ;

Rooney, CM ;

Heslop, HE .

JOURNAL OF EXPERIMENTAL MEDICINE, 2004, 200 (12) :1623-1633

[7] Eradication of systemic B-cell tumors by genetically targeted human T lymphocytes co-stimulated by CD80 and interleukin-15 [J].

Brentjens, RJ ;

Latouche, JB ;

Santos, E ;

Marti, F ;

Gong, MC ;

Lyddane, C ;

King, PD ;

Larson, S ;

Weiss, M ;

Rivière, I ;

Sadelain, M .

NATURE MEDICINE, 2003, 9 (03) :279-286

[8]

CHEEVER MA, 1977, J IMMUNOL, V119, P714

[9] Recognition of fresh human tumor by human peripheral blood lymphocytes transduced with a bicistronic retroviral vector encoding a murine anti-p53 TCR [J].

Cohen, CJ ;

Zheng, ZL ;

Bray, R ;

Zhao, YB ;

Sherman, LA ;

Rosenberg, SA ;

Morgan, RA .

JOURNAL OF IMMUNOLOGY, 2005, 175 (09) :5799-5808

[10] Enhanced antitumor activity of T cells engineered to express T-cell receptors with a second disulfide bond [J].

Cohen, Cyrille J. ;

Li, Yong F. ;

El-Gamil, Mona ;

Robbins, Paul F. ;

Rosenberg, Steven A. ;

Morgan, Richard A. .

CANCER RESEARCH, 2007, 67 (08) :3898-3903

← 1 2 3 4 5 6 7 8 →